Titolo Life-span exposure to sinusoidal-50Hz magnetic field and acute low-dose gamma radiation induce carcinogenic effects in Sprague-Dawley rats.
Rivista Int J Radiat Biol.
Numero 2016 Feb 19:1-13. [Epub ahead of print]
Autori Soffritti M1, Tibaldi E1, Padovani M1, Hoel DG2, Giuliani L3, Bua L1, Lauriola M1, Falcioni L1, Manservigi M1, Manservisi F1, Panzacchi S1, Belpoggi F1.
  • 1a Cesare Maltoni Cancer Research Center, Ramazzini Institute, Castello di Bentivoglio , Bentivoglio , Bologna , Italy ;
  • 2b Medical University of South Carolina , Charleston , SC , USA ;
  • 3c National Institute for Insurance Against Injuries at Work (INAIL) , Firenze , Italy.
Link http://www.ncbi.nlm.nih.gov/pubmed/26894944



BACKGROUND: Nel 2002, l'Agenzia Internazionale per la Ricerca sul Cancro (IARC) ha classificato i campi magnetici a frequenza estremamente bassa [extremely low frequency magnetic fields (ELFMF)] come un possibile agente cancerogeno sulla base dell'evidenza epidemiologica. I test biologici sperimentali su ratti e topi eseguiti fino ad ora sull'effetto singolo o combinato (in associazione con cancerogeni noti) di ELFMF non sono riusciti a fornire una risposta definitiva.

OBIETTIVI: Studiare gli effetti cancerogeni dell'esposizione combinata a campi magnetici sinusoidali a 50 Hz (S-50Hz) ed esposizione acuta a raggi gamma in ratti Sprague-Dawley.

METODI: Sono stati studiati gruppi di ratti Sprague-Dawley maschi e femmine esposti dalla vita prenatale fino alla loro morte naturale a campi magnetici S-50Hz a 20 o 1000 μT e anche a radiazione gamma da 0.1 Gy somministrata in una singola esposizione acuta a sei settimane di età.

RISULTATI: I risultati dello studio hanno mostrato significativi effetti cancerogeni per la ghiandola mammaria nei maschi e nelle femmine e un significativo aumento nell'incidenza di schwannomas maligni cardiaci come pure un'aumentata incidenza dei linfomi/leucemie nei maschi.

CONCLUSIONI: Questi risultati richiedono una rivalutazione della sicurezza delle radiazioni non ionizzanti.



"Conclusions -The results of this study have demonstrated for the first time that exposure to S-50Hz MF from prenatal life until natural death enhances the carcinogenic effects of γ radiations in male and female Sprague-Dawley rats.

The results of our study cannot be compared to those of the studies conducted in the past because of our different experimental design, large number of animals per group, starting exposure from prenatal life and duration of observation until natural death, our complete histopathological evaluation of all organs and tissues, as well as the possibility we had of comparing the incidence of various tumors in rats treated with 0.1 Gy and among negative controls as well as with concurrent males and females exposed to 1000 μT MF alone.

The type and level of 0.1 Gy exposure planned for this study cannot be considered unusual in the human working place or in general life. For instance, during computed tomography (CT) investigations, the organ being studied typically receives a radiation dose from 15 mGy (in adults) to 30 mGy (in children) with an average of 2–3 scans per study (which corresponds at least to 120 mGy, which is >0.1 Gy) (Brenner & Hall 2007). Radiation exposure from CT scans and increased cancer risk in adults (Sodickson et al. 2009) and in children (Pearce et al. 2012) has been reported. Moreover S-50Hz MF may enhance progression of a number of lesions from benign to malignant. Indeed, our results on mammary cancer as well as on leukemia and malignant schwannomas of the heart should call attention to situations in which exposure to MF may be associated with exposure to low doses of well-known carcinogenic agents such as ionizing radiation or other chemical carcinogens.

In conclusion, in our opinion these results call for a re-evaluation of the safety of non-ionizing radiation particularly at this time when the pressure to move from conventional fuels-based mobility to electric mobility deserves high priority in the EU and US and other industrialized countries."